Growth hormone releasing peptide-2 (GHRP-2) is a synthetic ghrelin analogue. Like ghrelin,
it stimulates release of endogenous growth hormone from somatotrophs in the anterior
pituitary; also like ghrelin, it is synergistic with endogenous growth hormone releasinghormone (GHRH) as well as with synthetic GHRH analogues such as Sermorelin or
GRF(1-29). Whereas GHRP-2 and other ghrelin analogues increase the number of
somatotrophs involved in the GH pulse by inhibiting somatostatin, GHRH increases the
pulse amplitude per pituitary cell or somatotroph by other means.