Exemestane is a synthetic androgen analogue. It is a steroidal inhibitor of aromatase which
binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of
cholesterol to pregnenolone and the peripheral aromatization of androgen precursors into
estrogens. Exemestane has been associated with a low rate of serum enzyme elevations
during therapy and rare instances of clinically apparent liver injury.